MyBioSource.com's GRIA4 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The GRIA4 Antibody (Center) was generated using GluA4, GluR4, and GRIA4 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Glutamate receptors are the predominant excitatory
neurotransmitter receptors in the mammalian brain and are activated
in a variety of normal neurophysiologic processes. These receptors
are heteromeric protein complexes composed of multiple subunits,
arranged to form ligand-gated ion channels. The classification of
glutamate receptors is based on their activation by different
pharmacologic agonists. The subunit encoded by this gene belongs to
a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole
propionate)-sensitive glutamate receptors, and is subject to RNA
editing (AGA->GGA; R->G). Alternative splicing of this gene results
in transcript variants encoding different isoforms, which may vary
in their signal transduction properties. Some haplotypes of this
gene show a positive association with schizophrenia. [provided by
RefSeq]